“Use of Depo-subQ Provera 104 or Depo Provera may cause you to lose calcium stored in your bones. The longer you use Depo Provera, the more calcium you are likely to lose. The calcium may not return completely once you stop using Depo Provera. Loss of calcium may cause weak bones that could increase the risk that your bones might break, especially after menopause. It is not known whether your risk of developing osteoporosis may be greater if you are a teenager when you start to use Depo Provera. You should only use Depo Provera long term (more than 2 years) if other methods of birth control are not right for you”. 简译: 此药可能会使你失去骨头里的钙质, 使用的时间越长, 可能失去的钙质越多. 失去钙质会使你的骨头变弱, 增加骨折的几率, 尤其是在绝经之后. 即时你停用此药, 钙质可能无法恢复. 你只有在其他避孕方法都无法使用的情况下, 才应该考虑长期(2年或以上)使用次药.